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Zisuva 600/Zisuva 1200: Method of Preparation: Preparation of solutions for intravenous injection: 500 mg/100 mg powder for solution for injection or infusion: Water for Injection is the normal solvent. ZISUVA Injection 500/100 mg should be dissolved in 10 ml of solvent. This yields approximately 10.5 ml of solution for single-dose use. A transient pink coloration may or may not develop during reconstitution. Reconstituted solutions are normally colorless to Pale Yellow in color.
ZISUVA Injection should be administered within 20 min of reconstitution.
1000 mg/200 mg powder for solution for injection or infusion: Water for Injection is the normal solvent. ZISUVA Injection 1000 mg/200 mg should be dissolved in 20 ml of solvent. This yields approximately 20.9 ml of solution for single-dose use. A transient pink coloration may or may not develop during reconstitution. Reconstituted solutions are normally colorless to Pale Yellow in color.
ZISUVA Injection should be administered within 20 min of reconstitution.
Preparation of solutions for intravenous infusion: ZISUVA Injection vials are not suitable for multi-dose use.
500 mg/100 mg powder for solution for infection or infusion: ZISUVA Injection should be reconstituted as described previously for injection. Without delay the reconstituted solution should be added to 50 ml of infusion fluid using a minibag or in-line burette.
1000 mg/200 mg powder for solution for injection or infusion: ZISUVA Injection should be reconstituted as described previously for injection. Without delay the reconstituted solution should be added to 100 ml of infusion fluid using a minibag or in-line burette.
Incompatibilities: ZISUVA Injection should not be mixed with blood products, other proteinaceous fluids such as protein hydrolysates or with intravenous lipid emulsions.
If prescribed concomitantly with an aminoglycoside, the antibiotics should not be mixed in the syringe, intravenous fluid container or giving set because loss of activity of the aminoglycoside can occur under these conditions.
ZISUVA Injection solutions should not be mixed with infusions containing glucose, dextran or bicarbonate.
Special Precautions for Disposal: Single dose for IV use only. Discard any unused solution.
The reconstitution/dilution is to be made under aseptic conditions, The solution is to be inspected visually for particulate matter and discoloration prior to administration. The solution should only be used if the solution is clear and free from particles.
Any unused medicinal product or waste material should be disposed of in accordance with local requirements.
